Which of the following is true about antigen presentation, MHC involvement or T cell activation? Check all that apply.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Which of the following is true about antigen presentation, MHC involvement or T cell activation? Check all that apply.

 

A. TCR on CD8 T cells recognizes MHC II-peptide complexes as signal 1 for T cell activation

 

B. Signal 2 and 3 for T cell activation involve interaction of B7.1/B7.2 (CD80/CD86) on APC with CD28 on T cells and cytokine release, respectively

 

C. Many cell types express MHC I and load antigen on it, whereas professional APC present antigen loaded on MHC II

 

D. CD4 interacts with MHC II and CD8 with MHC I for antigen presentation by APC

 

E. TCR on CD4 T cells recognizes MHC II-peptide complexes as signal 1 for T cell activation

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