Identify which of the following statements regarding peptide–MHC molecule interactions are correct. (Select all that apply.) a. Peptides with different amino acid sequences may be able to bind to the same type of MHC molecule. b. Covalent bonds hold the peptide in the groove of the MHC molecule. c. The length of peptides bound by MHC class I molecules is shorter than that of those bound by MHC class II molecules. d. The groove of the MHC molecule is deep enough to accommodate two or more peptides. e. Binding pockets of MHC molecules anchor the side chains of only certain amino acids of the peptide. f. The amino- and carboxy-terminal amino acids of peptides are used for binding to MHC class I molecules, whereas amino acids along the length of the peptide are used for binding to MHC class II molecules. g. Only non-self peptides form stable interactions with MHC molecules. h. The type of MHC molecule presenting a non-self protein is informative regarding whether the pathogen originated from an intracellular or extracellular source.
Identify which of the following statements regarding peptide–MHC molecule interactions are correct. (Select all that apply.) a. Peptides with different amino acid sequences may be able to bind to the same type of MHC molecule. b. Covalent bonds hold the peptide in the groove of the MHC molecule. c. The length of peptides bound by MHC class I molecules is shorter than that of those bound by MHC class II molecules. d. The groove of the MHC molecule is deep enough to accommodate two or more peptides. e. Binding pockets of MHC molecules anchor the side chains of only certain amino acids of the peptide. f. The amino- and carboxy-terminal amino acids of peptides are used for binding to MHC class I molecules, whereas amino acids along the length of the peptide are used for binding to MHC class II molecules. g. Only non-self peptides form stable interactions with MHC molecules. h. The type of MHC molecule presenting a non-self protein is informative regarding whether the pathogen originated from an intracellular or extracellular source.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
Question
| Identify which of the following statements regarding peptide–MHC molecule interactions are correct. (Select all that apply.) |
| a. Peptides with different amino acid sequences may be able to bind to the same type of MHC molecule. |
| b. Covalent bonds hold the peptide in the groove of the MHC molecule. |
| c. The length of peptides bound by MHC class I molecules is shorter than that of those bound by MHC class II molecules. |
| d. The groove of the MHC molecule is deep enough to accommodate two or more peptides. |
| e. Binding pockets of MHC molecules anchor the side chains of only certain amino acids of the peptide. |
| f. The amino- and carboxy-terminal amino acids of peptides are used for binding to MHC class I molecules, whereas amino acids along the length of the peptide are used for binding to MHC class II molecules. |
| g. Only non-self peptides form stable interactions with MHC molecules. |
|
h. The type of MHC molecule presenting a non-self protein is informative regarding whether the pathogen originated from an intracellular or extracellular source.
|
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