Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self

Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter42: The Immune System

Section: Chapter Questions

Problem 1VCQ: Figure 42.11 Which of the following statements about T cells is false? Helper T cells release...

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Question

Match the term with its correct description.
Transcription factor required for T-cell development
Composed of superdimer, CD3 and zeta chain
Facilitates the expression of tissue-specific genes in thymic epithelium
Selection for thymocytes which recognize self MHC molecules
Elimination of thymocytes which recognize self
✓Choose...
Negative selection
Notch 1
Pre-T-cell receptor
Positive selection
AIRE
Choose...
➡

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Match the term with its correct description. Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self Negative selection Notch 1 Pre-T-cell receptor Positive selection ✓AIRE Choose... Choose... Choose... Choose... $ ✪
Match the T-cell component in Column A with its description in Column B. Use each description only once.
Match the term with its correct description Long, flexible molecule expressed on B-cells, macrophages and FDC which binds to C3d B-cell co-receptor Cognate pair Rapidly dividing cell which is going through somatic hypermutation Slowly dividing cell which searches for antigen match on FDC ✓Choose... CR2 Centrocyte CR2, CD19, CD81 TFH cell and B-cell which recognize same antigen Centroblast Choose... Choose... S
During the early developmental stages of α:β T cells in the thymus, there are two key checkpoints that must be satisfied to permit the progression of T-cell development. Explain what occurs at each checkpoint.
Determine which statement(s) are true/false NK cells are a type of lymphocyte involved in acquired immunity Plasma cells are a type of B- cell that directly bind antigens on target cells ✓ [Choose ] False True Binding of antigen to the cell surface of B-memory cells is a trigger for the secondary immune response Loss of MHC Class I expression would decrease the effectiveness of cytotoxic T-cell response [Choose ] [Choose ] [Choose ] >
All of the following statements concerning regulatory T cells (Treg) are correct, EXCEPT: The regulatory cytokines produced by regulatory T cells are IL-12 and TGF-B O Thymocytes that recognize self-antigen in the thymus with a certain affinity become natural (central) regulatory T cells O In the periphery T cells that recognize self-antigen in the presence of TGF-B become induced regulatory T cells O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized itself provided that the peptides are derived from the same tissue O A Treg cell can suppress self-reactive lymphocytes that recognize peptides different from that recognized by itself provided that the peptides are presented by the same antigen-presenting cell (APC)
There are several important mechanisms for generating diversity in immunoglobulin and T cell receptors. Explain the similarities and differences in mechanisms that generates diversity in these receptors.
At first glance, it would seem a dangerous strategyfor the thymus to actively promote the survival, matura-tion, and emigration of developing T cells that bind weaklyto self peptides bound to self MHC molecules. Would itnot be safer to get rid of these T cells, along with those thatbind strongly to such self-peptide–MHC complexes, as thiswould seem a more secure way to avoid autoimmune reac-tions?
Please Explain
Which two events are required to activate a cytotoxic T cell? There is more than one answer. O Class II MHC molecules present extracellular antigen for binding on a complementary cytotoxic T cell receptor. O IL-4 is released by a TH1 cell to be bound by a cytotoxic T cell. O Class I MHC molecules presents intracellular antigen for binding on a complementary cytotoxic T cell receptor O IL-2 is released by a TH1 cell to be bound by a cytotoxic T cell.
Match the term in Column A with its correct description in Column B.
T cells in the thymus are determined to be T helper cells or T killer cells while undergoing maturation in the Choose from the folloiwng: (A) cortex of the thymus (B) medulla of the thymus