Ingestion of complement-tagged pathogens by phagocytes is mediated by receptors for the bound complement proteins.  Even when the complement cascade fails to proceed beyond generating the C3 convertase, complement activation is effective at inducing pathogen uptake and destruction. This process of immune protection is mediated by: Activation of complement inhibitory receptors on phagocytes that promote pathogen uptake Activation of soluble proteases in the serum that disrupt pathogen membranes Engagement of complement receptors on phagocytes by C3b and its cleavage products which promotes phagocytosis Engagement of complement receptors on B cells that promotes antibody production Stimulation of antimicrobial peptide secretion by phagocytes

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Ingestion of complement-tagged pathogens by phagocytes is mediated by receptors for the bound complement proteins.  Even when the complement cascade fails to proceed beyond generating the C3 convertase, complement activation is effective at inducing pathogen uptake and destruction. This process of immune protection is mediated by:

  1. Activation of complement inhibitory receptors on phagocytes that promote pathogen uptake
  2. Activation of soluble proteases in the serum that disrupt pathogen membranes
  3. Engagement of complement receptors on phagocytes by C3b and its cleavage products which promotes phagocytosis
  4. Engagement of complement receptors on B cells that promotes antibody production
  5. Stimulation of antimicrobial peptide secretion by phagocytes
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