During MHC class I synthesis and folding in the endoplasmic reticulum (ER), a process of peptide editing takes place as the newly synthesized MHC class I protein is held in a ‘peptide receptive’ state by binding to the calreticulin:ERp57:tapasin complex. Peptide editing ensures that the MHC class I molecules that reach the cell surface have stable, high affinity binding for their peptide cargo. Peptide editing is important to the immune response because it: Maintains high levels of surface MHC class I expression Ensures that MHC class I molecules are not degraded in the ER Retains the nascent MHC class I molecule in a peptide receptive state Allows surface MHC class I molecules to bind new peptides from the extracellular milieu Prevents surface MHC class I molecules from undergoing peptide exchange at the cell surface
During MHC class I synthesis and folding in the endoplasmic reticulum (ER), a process of peptide editing takes place as the newly synthesized MHC class I protein is held in a ‘peptide receptive’ state by binding to the calreticulin:ERp57:tapasin complex. Peptide editing ensures that the MHC class I molecules that reach the cell surface have stable, high affinity binding for their peptide cargo. Peptide editing is important to the immune response because it: Maintains high levels of surface MHC class I expression Ensures that MHC class I molecules are not degraded in the ER Retains the nascent MHC class I molecule in a peptide receptive state Allows surface MHC class I molecules to bind new peptides from the extracellular milieu Prevents surface MHC class I molecules from undergoing peptide exchange at the cell surface
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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During MHC class I synthesis and folding in the endoplasmic reticulum (ER), a process of peptide editing takes place as the newly synthesized MHC class I protein is held in a ‘peptide receptive’ state by binding to the calreticulin:ERp57:tapasin complex. Peptide editing ensures that the MHC class I molecules that reach the cell surface have stable, high affinity binding for their peptide cargo. Peptide editing is important to the immune response because it:
- Maintains high levels of surface MHC class I expression
- Ensures that MHC class I molecules are not degraded in the ER
- Retains the nascent MHC class I molecule in a peptide receptive state
- Allows surface MHC class I molecules to bind new peptides from the extracellular milieu
- Prevents surface MHC class I molecules from undergoing peptide exchange at the cell surface
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