Secondary lymphoid organs (SLOs) are important sites for the initiation of T cell responses via immune priming. Once an antigen-presenting cell (APC) presenting peptide-MHC arrives at a secondary lymphoid organ, it must find a relatively rare T cell clone with a TCR that recognizes its presented peptide-MHC complex. Which of the following features of SLOs increases the likelihood of this APC finding its cognate T cell? Activated APCs are captured by SLO-resident macrophages once they enter via afferent lymphatics, allowing them to be interrogated by T cells Concentrate high densities of T cells within specific zones to enable efficient APC browsing Drain pathogens from infected tissues through the lymphatics, bringing them to secondary lymphoid organs where they can be killed by B cells Contain specialized nutrients that are required for productive TCR signaling following interactions with a cognate APC
Secondary lymphoid organs (SLOs) are important sites for the initiation of T cell responses via immune priming. Once an antigen-presenting cell (APC) presenting peptide-MHC arrives at a secondary lymphoid organ, it must find a relatively rare T cell clone with a TCR that recognizes its presented peptide-MHC complex.
Which of the following features of SLOs increases the likelihood of this APC finding its cognate T cell?
When an antigen enters into the human body, then the acute inflammation occured immediately . After the initiation of the acute inflammation , the cells of the innate immune system , which are antigen presenting cells APCs like the macrophages , dendritic cells phagocytoses the inheriting antigen . When they have invaded the antigen , the antigen presenting cells , will enter into the lymphatic vessel and they will enter into the draining lymph node. Then in the draing lyph mode , these antigen presenting cells will activate the lymphocytes and thus they will cause the activation of the adaptive immune system .
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