in several populations, SNPs were genotyped for the major histocompatibility class (MHC) II region in a large number of human couples. Each individual was compared with another random individual of the opposite sex and a mean relatedness coefficient calculated, where a positive value indicates more related than average. This was repeated 100,000 times and the results were plotted as a blue histogram for each population. The mean measure

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in several populations, SNPs were genotyped for the major histocompatibility class (MHC) II region in a large number of human couples. Each individual was compared with another random individual of the opposite sex and a mean relatedness coefficient calculated, where a positive value indicates more related than average. This was repeated 100,000 times and the results were plotted as a blue histogram for each population. The mean measure of relatedness at the MHC class II region was then calculated for actual couples, and plotted as a red vertical line.

Which of the following statements is correct?

 

  A.

Couples in the UK are more dissimilar at the MHC than couples in Spain

  B.

Couples in the Netherlands are more dissimilar at the MHC than couples in Israel

  C.

Couples in the Netherlands are more similar at the MHC than couples in Israel

  D.

There is less diversity at the MHC class II region between the individuals from Belgium compared to between the individuals in the Netherlands

 

20 000
10 000-
5000-
0.
15 000
10 000-
5000
0
Northern Europe
-0.04-0.02 0 0.02 0.04
Netherlands
-0.04-0.02 0 0.02 0.04
5000-
3000-
1000
0-
10 000
6000-
2000
0-
Belgium
-0.04-0.02 0 0.02 0.04
UK
-0.04-0.02
8000-
6000-
4000-
2000-
0
8000-
6000
4000-
2000-
0
Ireland
-0.04-0.02 0 0.02 0.04
Spain
0 0.02 0.04
-0.04-0.02 0
mean relatedness coefficient between spouses
0.02 0.04
10 000
6000
2000-
0
14 000
10 000-
6000-
2000-
0
Germany
-0.04 -0.02 0 0.02 0.04
Israel
-0.04-0.02 0
0.02 0.04
Transcribed Image Text:20 000 10 000- 5000- 0. 15 000 10 000- 5000 0 Northern Europe -0.04-0.02 0 0.02 0.04 Netherlands -0.04-0.02 0 0.02 0.04 5000- 3000- 1000 0- 10 000 6000- 2000 0- Belgium -0.04-0.02 0 0.02 0.04 UK -0.04-0.02 8000- 6000- 4000- 2000- 0 8000- 6000 4000- 2000- 0 Ireland -0.04-0.02 0 0.02 0.04 Spain 0 0.02 0.04 -0.04-0.02 0 mean relatedness coefficient between spouses 0.02 0.04 10 000 6000 2000- 0 14 000 10 000- 6000- 2000- 0 Germany -0.04 -0.02 0 0.02 0.04 Israel -0.04-0.02 0 0.02 0.04
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