refer to this paper: Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice What is the question that this research aims to answer?
refer to this paper: Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
What is the question that this research aims to answer?
Figure 2. Look at each of these graphs and indicate the differences or similarities between each group of mice (WT CAS-HF, WT SPI-HF, MOD-1 CAS-HF, MOD-1 SPI-HF).
Figure 3.A. What causes insulin release? Why is insulin being looked at (look in the discussion section)
- Where is leptin produced? What does it do?
- What is adiponectin? What does it do?
- What does a high leptin/adiponectin ratio mean? (Hint: Look at the introduction section).
Figure 4. What is mTOR (look at the discussion section)?
- What enzymes/proteins were significantly different between the WT and MOD-1 mice? What enzymes/proteins were significantly different between the CAS-HF diet and the SPI-HF diet?
- Answer the same two questions above. Is there any difference between what was found in the distal colon compared to the jejunum?
- What is B-Actin?
Figure 5. B. Crypt depth is smaller in MOD-1 mice than WT mice? What is a potential reason for this?
Figure 6. B/C. What is oil red o staining? What do you notice between the photos in part C?
Figure 7. A. What are IRS1 and IRS2?
- What tissue type is this?
- Is adipocyte area the same or different between the four mice groups?
What were the results of this study?
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