You expect that a lung tumor cell line has arisen due to aberrant expression of the growth factor receptor kit. The kit gene is a tyrosine kinase growth factor receptor that is activated by the growth factor called Stem Cell Factor. There is no evidence that the amino acid sequence of the kit gene is altered. Western blot determination of protein expression in lung cells from two cancer patients (lanes 1 and 2) and a normal donor (Lane 3) are depicted below. Given this data explain the likely mechanism of how the altered expression of kit is leading to a proliferative state (limit 4-5 sentences). 1 2 3 ) SCF c-kit (125 kDa) 38 kDa 35 kDa

Q: A light-haired man has blood type O, his wife has dark hair and blood type AB, but her father had…

A: DNA is the molecule that carries genetic information. A specific sequence of DNA that expresses a…

Q: Mutant C has had the first 5 base pairs deleted (position 1-5). Does this mutation change the…

A: Translation is the process which is responsible for synthesis of protein from the mRNA.

Q: What would be the likely phenotypic effect of a mutation in HOTAIR and prevented it from binding to…

A: HOTAIR (HOX antisense intergenic RNA) is a long non-coding RNAs with 6 exons and 2158 nucleotides…

Q: The lac repressor and the pur repressor are homologous proteins with very similar three-dimensional…

A: The lac represser supermolecule, LacI, prevents the transcription of genes concerned in lactose…

Q: The GA(T>C)A mutation in the Duffy promoter impacted expression of Duffy in the following cell…

A: The promoter is the region where the RNA polymerase binds during the transcription i.e. synthesis of…

Q: To identify transcriptional regulatory elements, reporters containing 100 base pairs of Promoter…

A: Transcriptional regulatory elements are the genetic segments that act as the binding sites for…

Q: Match each of the following descriptions to the type of regulatory RNA affecting a "target" gene…

A: Of course! Let's break down each match:This regulatory RNA may increase transcription of the target…

Q: A second hit might occur through epigenetic modification. There is a CpG island in the RB1 promoter.…

A: CpG islands are regions of DNA that are rich in CpG dinucleotides, and they are often located near…

Q: in a fat cell what is the result of activation of genes by PPAR gamma/activator proteins binding?…

A: Peroxisome proliferator - activated receptor(PPAR) gamma is a  nuclear receptor of subfamily 1,group…

Q: MSH2 is a gene commonly associated with HNPCC (Hereditary nonpolyposis colorectal cancer). This gene…

A: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an inherited…

Q: Explain

A: The process by which information encoded in a gene is used to control the assembly of a protein…

Q: Concentration (%) A researcher is studying environmental conditions that cause the expression of…

A: We analyze the correlation between pH values and active repressor concentration to identify the…

Q: A which is involved in the silencing of the y-globin gene, is rendered inactive. CL11A is a Land a…

A: Gene silencing is a negative feedback process that controls gene expression and metabolism…

Q: How many of the mutations listed below would lead to excessive cell growth when the cell was either…

A: Excessive growth occurs when a cell continuously divides and when there is no cell cycle arrest. Myc…

Q: stream of their coding sequence. The interaction of these enhancers with specific pression. Gene A…

A: Transcription elements Are defined as the type of proteins that have the ability to do modification…

Q: GC (Glycocorticoids) binds to the glucocorticoid receptor (GR), which leads to the transcription of…

A: Receptors are structures made of proteins that transduce signals in the cells upon binding of the…

Q: The IMD2 promoter contains three upstream transcription start sites (TSS) that are utilized under…

A: Inosine monophosphate dehydrogenase (IMD2) is a key enzyme in the purine biosynthesis pathway that…

Q: xplain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

A: MMP stands for matrix metalloproteinase is a multi-functional factor that plays a crucial role in…

Q: Based on the labels you should be able to recognize the characteristic structure depicted below and…

A: Introduction The Process Of Turning Nucleic Acid Information Into Amino Acids Is Known As…

Q: Retinoblastoma is an extremely rare cancer of the retina in the eye. The disease mainly affects…

A: The investigation into retinoblastoma, a uncommon eye cancer fundamentally influencing children,…

Q: gamma:delta T-cell receptors are also generated by gene rearrangement. Some T cells express…

A: Introduction: The gamma-delta T cells are the ones that display a typical T cell receptor on their…

Q: TOH1 protein is typically expressed at the same level in kidney and stomach cells and is essential…

A: Microarray is used to detect the expression of thousands of genes at the same time. DNA microarrays…

Q: How would you identify patients whose tumor cells are particularly likely to have a somatic mutation…

A: Somatic mutation takes place in all types of cells in the body except the germ cells. Therefore…

Q: Using RNA-seq analysis of transcripts isolated from different organs in mice, you find that the…

A: The gene is the sequence of DNA which can code for the functional protein. The lacZ is the reporter…

Q: you are provided with a protein "X" having an expression rate of 10 mg/dl, how you can enhance the…

A: Activators improve the interaction of RNA polymerase with a specific promoter, facilitating the gene…

Q: A pharmaceutical company developed a drug, CP788, that inhibits the interaction of Grb2 with SH2…

A: Grb2 ( growth factor receptor bound protein 2) is an adaptor protein whose function is to bring…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: GR and PPAR are transcription factors that bind to GRE and PPARE sequences respectively  and…

A: A reporter cell line is a stable cell line that has been labeled with a reporter gene, allowing the…

Q: S-Cdk is likely to be a [Select] The inhibitor of Ras is likely to be a [ Select] < The MAP kinase…

A: Cell signaling is the process by which cells communicate with each other and respond to signals from…

Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.