Homework Help is Here – Start Your Trial Now!
Science
Biology
xplain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

xplain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question

 mice were treated with a virus that inhibited expression of angiopoietin 2, MMP3 and MMP10 in the lung or with a control virus (Mock). Breast cancer cells that express the gene luciferase were then injected into the mammary glands of the mice. The metstasis of the tumors to the lungs could then be measured by imaging the presence of luciferase in the lungs. In 5-6 sentences, explain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis. 

# Analysis of Tumor Growth and Inhibition in Vivo ## Figure A: In Vivo Imaging This figure displays in vivo imaging results from a study on tumor growth. The imaging is divided into two rows, showcasing different conditions over a 6-week period (W1 to W6). - **Top Row (Mock):** These images illustrate the progression of tumor growth under the control condition (Mock). Over the weeks, there is a noticeable increase in colored areas, particularly red, indicating high levels of activity or tumor growth. The color scale on the right shows photon flux levels, with red indicating the highest levels (up to 20,000). - **Bottom Row (Angpt2/MMP3/10-RNAi):** These images demonstrate the effect of administering Angpt2/MMP3/10-RNAi treatment. The lack of significant color or activity throughout the weeks suggests inhibition of tumor growth. ## Figure B: Quantitative Analysis of Photon Flux This graph provides a quantitative analysis of the relative photon flux in the two treatment groups over a period of 6 weeks. - **Y-Axis (Relative Photon Flux):** Measures the intensity of photon emission, which is an indicator of tumor growth. - **X-Axis (Weeks):** Displays the timeline in weeks from 0 to 6. - **Data Points:** - **Blue Circles (Mock):** Show a significant increase in photon flux, indicating higher tumor activity. - **Red Triangles (Angpt2/MMP3/10-RNAi):** Show a much lower level of photon flux, suggesting effective tumor growth inhibition. - **Error Bars:** Represent standard deviation, showing the variability and reliability of the data. Overall, the results highlight the effectiveness of Angpt2/MMP3/10-RNAi in reducing tumor growth compared to the control.
Transcribed Image Text:# Analysis of Tumor Growth and Inhibition in Vivo ## Figure A: In Vivo Imaging This figure displays in vivo imaging results from a study on tumor growth. The imaging is divided into two rows, showcasing different conditions over a 6-week period (W1 to W6). - **Top Row (Mock):** These images illustrate the progression of tumor growth under the control condition (Mock). Over the weeks, there is a noticeable increase in colored areas, particularly red, indicating high levels of activity or tumor growth. The color scale on the right shows photon flux levels, with red indicating the highest levels (up to 20,000). - **Bottom Row (Angpt2/MMP3/10-RNAi):** These images demonstrate the effect of administering Angpt2/MMP3/10-RNAi treatment. The lack of significant color or activity throughout the weeks suggests inhibition of tumor growth. ## Figure B: Quantitative Analysis of Photon Flux This graph provides a quantitative analysis of the relative photon flux in the two treatment groups over a period of 6 weeks. - **Y-Axis (Relative Photon Flux):** Measures the intensity of photon emission, which is an indicator of tumor growth. - **X-Axis (Weeks):** Displays the timeline in weeks from 0 to 6. - **Data Points:** - **Blue Circles (Mock):** Show a significant increase in photon flux, indicating higher tumor activity. - **Red Triangles (Angpt2/MMP3/10-RNAi):** Show a much lower level of photon flux, suggesting effective tumor growth inhibition. - **Error Bars:** Represent standard deviation, showing the variability and reliability of the data. Overall, the results highlight the effectiveness of Angpt2/MMP3/10-RNAi in reducing tumor growth compared to the control.
Expert Solution
steps

Step by step

Solved in 3 steps with 1 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Clinical pharmacology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS