MDF57 is a 110kDa DNA binding protein which has some functional roles in the development of lymphomas. In the SDS-PAGE gel, a MW marker is shown followed by the "control" lane, with a sample of recombinant protein "MDF57". Lane 1 shows proteins that have been prepared from leukocytes from a normal, healthy individual. Lanes 2, 3, 4, 5 and 6 show protein prepared from leukocytes from individuals with lymphoma. What is the best explanation for the result shown for patient 3? 250 180 160 140 120 100 60 40 20 MW Marker Control 1 2 ||||0|||0 ||||0|||0||| O Translocation of MDF gene O Duplication of MDF57 gene O Deletion of MDF57 gene Point mutation of MDF57 gene Normal expression of MDF57 gene 5 ||||0|||0|| |||||||||||||

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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MDF57 is a 110kDa DNA binding protein which has some functional roles in the development of lymphomas. In the SDS-PAGE gel, a MW marker is shown followed by the
"control" lane, with a sample of recombinant protein "MDF57". Lane 1 shows proteins that have been prepared from leukocytes from a normal, healthy individual. Lanes 2, 3, 4, 5
and 6 show protein prepared from leukocytes from individuals with lymphoma. What is the best explanation for the result shown for patient 3?
250
180
160
140
120
100
60
40
20
MW
Marker Control
1 2
Translocatio
F57 gene
Duplication of MDF57 gene
Deletion of MDF57 gene
Point mutation of MDF57 gene
Normal expression of MDF57 gene
5
||||||||||||
|||||||||||
6
Transcribed Image Text:MDF57 is a 110kDa DNA binding protein which has some functional roles in the development of lymphomas. In the SDS-PAGE gel, a MW marker is shown followed by the "control" lane, with a sample of recombinant protein "MDF57". Lane 1 shows proteins that have been prepared from leukocytes from a normal, healthy individual. Lanes 2, 3, 4, 5 and 6 show protein prepared from leukocytes from individuals with lymphoma. What is the best explanation for the result shown for patient 3? 250 180 160 140 120 100 60 40 20 MW Marker Control 1 2 Translocatio F57 gene Duplication of MDF57 gene Deletion of MDF57 gene Point mutation of MDF57 gene Normal expression of MDF57 gene 5 |||||||||||| ||||||||||| 6
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