In addition to the effect on ribonucleotide reductase, hydroxyurea causes changes at the gene expression level. In the presence of hydroxyurea, the transcription factor GATA2 becomes upregulated, turning on the expression of the y-globin gene, while the transcription factor BCL11A which is involved in the silencing of the y-globin gene, is rendered inactive. Q6: BCL11A is a and a transcriptional of the y-globin gene.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
In addition to the effect on ribonucleotide reductase, hydroxyurea causes changes at the gene expression level. In the presence of hydroxyurea, the transcription factor GATA2 becomes upregulated, turning on the expression of the y-globin gene, while the transcription factor BCL11A which is involved in the silencing of the y-globin gene, is rendered inactive.
Q6: BCL11A is a and a transcriptional of the y-globin gene.
Step by step
Solved in 2 steps
