GC (Glycocorticoids) binds to the glucocorticoid receptor (GR), which leads to the transcription of a series of genes (PC, PCK1, FBP1, PFKFB1, G6PC and G6P transporter (SLC37A4)) involved in gluconeogenesis.What type of receptor is GR?Where would you expect the activated GR to be located to enhance the expression of the gluconeogenic genes?Which cis-acting elements are used by GR as an activator to turn gene transcription “on”?

Answered: GC (Glycocorticoids) binds to the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

GC (Glycocorticoids) binds to the glucocorticoid receptor (GR), which leads to the transcription of a series of genes (PC, PCK1, FBP1, PFKFB1, G6PC and G6P transporter (SLC37A4)) involved in gluconeogenesis.

What type of receptor is GR?
Where would you expect the activated GR to be located to enhance the expression of the gluconeogenic genes?
Which cis-acting elements are used by GR as an activator to turn gene transcription “on”?

Expert Solution

Introduction

Receptors are structures made of proteins that transduce signals in the cells upon binding of the ligand. Once a ligand binds the receptor, the receptor undergoes a conformational change that allows it to transmit signals inside the cell.

Types of receptors include: