Ferritin levels are controlled in cells to ensure that free iron levels do not surpass a toxic threshold. Its levels must never be too high or it will titrate too much iron and jeapardize critical cellular iron-dependent enzyme activities. How is this achieved? Choose one.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Ferritin levels are controlled in cells to ensure that free iron levels do not surpass a toxic threshold. Its levels must never be too high or it will titrate too much iron and jeapardize critical cellular iron-dependent enzyme activities. How is this achieved? Choose one.

a) Elements present in the 5' UTR contribute to its translational block in low iron conditions.
b) The Ferritin mRNA is under IRE-BP control so that in high iron conditions IRE-BP is not in its active conformation an has no negative effect on Ferritin mRNA translation
c) IRE-BP can effectively bind to destablizing elements in the 3'UTR of the Ferritin mRNA, thus drastically reducing the half life of the transcript
4) a and b only
5) a, b and c
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