Proteins that are retained in the ER have a KDEL sequence at their C-terminus. To test the idea that KDEL is both necessary and sufficient for retention in the ER, two experiments were performed. First, it was deleted from protein disulfide isomerase (PDI), and this form of PDI got secreted. Second, it was attached to a peptide growth hormone, which is
Proteins that are retained in the ER have a KDEL sequence at their C-terminus. To test the idea that KDEL is both necessary and sufficient for retention in the ER, two experiments were performed. First, it was deleted from protein disulfide isomerase (PDI), and this form of PDI got secreted. Second, it was attached to a peptide growth hormone, which is normally secreted from the cell. This modified peptide still got secreted. Which interpretation does this support?
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The data do not allow for an interpretation, additional experiments are needed. |
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KDEL is sufficient but not necessary for ER retention. |
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KDEL is both necessary and sufficient for ER retention. |
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KDEL is necessary but not sufficient for ER retention. |
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