Aurora A Aurora A is a protein that acts as a kinase (transfers phosphates to molecules). Many types of cancer cells, including breast cancer cells, have higher than normal levels of this protein. Expressions of Aurora A genes in normal breast tissues (n = 10), normal tissues adjacent to tumors (n = 12) and breast tumors (n = 14). Scientists studying the production of Aurora A protein in normal frog cells observed that the amount of this protein in the cells changed throughout the cell cycle. Scientists tested chemicals that block Aurora 2 to see if they could be used as anti-cancer drugs. They found that some of the candidate drugs did slow the growth of cancer cells in cell culture in the lab. But when they tested these drugs in cancer patients to see if the drugs could slow the growth of solid tumors, they found that the benefit to patients was small when compared to the development of severe side effects such as anemia (low red blood cell count) and leukopenia (low white blood cell count). Which of the following explanations best fits these observations? Group of answer choices 1. The cells that produce blood cells divide more rapidly than the cells in the patients' tumors. 2. Cancer cells need aurora 2 to divide, but the cells that produce blood cells don't. 3. The cells that produce blood cells divide more slowly than the cells in the patients' tumors. 4. Cancer cells don't need aurora 2 to divide, but the cells that produce blood cells do.

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Aurora A
Aurora A is a protein that acts as a kinase (transfers phosphates to molecules). Many types of cancer cells, including breast cancer cells, have higher than normal levels of this protein.

Expressions of Aurora A genes in normal breast tissues (n = 10), normal tissues adjacent to tumors (n = 12) and breast tumors (n = 14).

Scientists studying the production of Aurora A protein in normal frog cells observed that the amount of this protein in the cells changed throughout the cell cycle.

Scientists tested chemicals that block Aurora 2 to see if they could be used as anti-cancer drugs. They found that some of the candidate drugs did slow the growth of cancer cells in cell culture in the lab. But when they tested these drugs in cancer patients to see if the drugs could slow the growth of solid tumors, they found that the benefit to patients was small when compared to the development of severe side effects such as anemia (low red blood cell count) and leukopenia (low white blood cell count). Which of the following explanations best fits these observations?

Group of answer choices

1. The cells that produce blood cells divide more rapidly than the cells in the patients' tumors.

2. Cancer cells need aurora 2 to divide, but the cells that produce blood cells don't.

3. The cells that produce blood cells divide more slowly than the cells in the patients' tumors.

4. Cancer cells don't need aurora 2 to divide, but the cells that produce blood cells do.

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