Molecular genetic studies are performed on a family with known familial hypercholesterolemia. In this particular family, the defect in the LDL receptor gene involves a messenger mutation near the 11th exon, in the region of homology with epidermal growth factor receptor precursor. A defect at this site would be most likely to produce which of the following effects? A. Decreased transcription of LDL receptor gene B. Poor internalization of LDL bound to LDL receptor C. Poor retention of the LDL receptor in the membrane D. Reduced binding of LDL E. Trapping of the LDL receptor in the endoplasmic reticulum

Molecular genetic studies are performed on a family with known familial hypercholesterolemia. In this particular family, the defect in the LDL receptor gene involves a messenger mutation near the 11th exon, in the region of homology with epidermal growth factor receptor precursor. A defect at this site would be most likely to produce which of the following effects? A. Decreased transcription of LDL receptor gene B. Poor internalization of LDL bound to LDL receptor C. Poor retention of the LDL receptor in the membrane D. Reduced binding of LDL E. Trapping of the LDL receptor in the endoplasmic reticulum

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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