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B. Shiga toxin (Stx) is a potent A-B toxin that inhibits protein synthesis and has a lethal dose 50 (LD50) of approximately 20 ng/kg of body weight in rabbits (meaning that 1 µg of Stx would be lethal for half the people exposed to this dose). Nonetheless, cell lines derived from different mammalian tissues range from highly susceptible (cytotoxic dose 50 [CD50] of approximately 10 pg/ml) to completely resistant (CD50 > 1 µg/ml). What cellular or molecular differences do you think account for susceptibility and resistance of these cell lines? Note: LD50 is the dose at which 50% of the test subjects die. In this case, it was determined for rabbits given intravenous injections of the toxin. CD50 is the concentration at which 50% of the cells die. Measure mostly used for tissue culture lab experiment.

B. Shiga toxin (Stx) is a potent A-B toxin that inhibits protein synthesis and has a lethal dose 50 (LD50) of approximately 20 ng/kg of body weight in rabbits (meaning that 1 µg of Stx would be lethal for half the people exposed to this dose). Nonetheless, cell lines derived from different mammalian tissues range from highly susceptible (cytotoxic dose 50 [CD50] of approximately 10 pg/ml) to completely resistant (CD50 > 1 µg/ml). What cellular or molecular differences do you think account for susceptibility and resistance of these cell lines? Note: LD50 is the dose at which 50% of the test subjects die. In this case, it was determined for rabbits given intravenous injections of the toxin. CD50 is the concentration at which 50% of the cells die. Measure mostly used for tissue culture lab experiment.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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B. Shiga toxin (Stx) is a potent A-B toxin that inhibits protein synthesis and has a lethal dose 50 (LD50) of approximately 20 ng/kg of body weight in rabbits (meaning that 1 µg of Stx would be lethal for half the people exposed to this dose). Nonetheless, cell lines derived from different mammalian tissues range from highly susceptible (cytotoxic dose 50 [CD50] of approximately 10 pg/ml) to completely resistant (CD50 > 1 µg/ml). What cellular or molecular differences do you think account for susceptibility and resistance of these cell lines? Note: LD50 is the dose at which 50% of the test subjects die. In this case, it was determined for rabbits given intravenous injections of the toxin. CD50 is the concentration at which 50% of the cells die. Measure mostly used for tissue culture lab experiment.
Transcribed Image Text:B. Shiga toxin (Stx) is a potent A-B toxin that inhibits protein synthesis and has a lethal dose 50 (LD50) of approximately 20 ng/kg of body weight in rabbits (meaning that 1 µg of Stx would be lethal for half the people exposed to this dose). Nonetheless, cell lines derived from different mammalian tissues range from highly susceptible (cytotoxic dose 50 [CD50] of approximately 10 pg/ml) to completely resistant (CD50 > 1 µg/ml). What cellular or molecular differences do you think account for susceptibility and resistance of these cell lines? Note: LD50 is the dose at which 50% of the test subjects die. In this case, it was determined for rabbits given intravenous injections of the toxin. CD50 is the concentration at which 50% of the cells die. Measure mostly used for tissue culture lab experiment.
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