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If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what affect, if any, would this have on the UPR (unfolded protein response). O A. Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. B. Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes C. MRNA would not be imported into the nucleus thus preventing transcription of UPR response genes D. Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes O E. No effect, these are completely unrelated processes.

If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what affect, if any, would this have on the UPR (unfolded protein response). O A. Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. B. Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes C. MRNA would not be imported into the nucleus thus preventing transcription of UPR response genes D. Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes O E. No effect, these are completely unrelated processes.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Question:** If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what effect, if any, would this have on the UPR (unfolded protein response). - **A.** Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. - **B.** Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes. - **C.** mRNA would not be imported into the nucleus thus preventing transcription of UPR response genes. - **D.** Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes. - **E.** No effect, these are completely unrelated processes. **Explanation:** This question evaluates the impact of an importin mutation on the UPR. Importins typically transport cargo proteins into the nucleus by recognizing their nuclear localization signals (NLS). When a mutation disrupts this interaction, it affects the nuclear transport pathway, potentially impeding gene regulation, especially for responses requiring protein import into the nucleus, such as the UPR.
Transcribed Image Text:**Question:** If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what effect, if any, would this have on the UPR (unfolded protein response). - **A.** Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. - **B.** Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes. - **C.** mRNA would not be imported into the nucleus thus preventing transcription of UPR response genes. - **D.** Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes. - **E.** No effect, these are completely unrelated processes. **Explanation:** This question evaluates the impact of an importin mutation on the UPR. Importins typically transport cargo proteins into the nucleus by recognizing their nuclear localization signals (NLS). When a mutation disrupts this interaction, it affects the nuclear transport pathway, potentially impeding gene regulation, especially for responses requiring protein import into the nucleus, such as the UPR.
Expert Solution
Step 1

Importin is a protein that transports various substances to nucleus via nuclear localization signal.

Unfolded protein response (UPR) is a process in which the protein degrading function of endoplasmic reticulum is enhanced in response to incorrectly folded proteins.

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