Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in
Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers
| A. |
Mutation of active site residue responsible for tyrosine phosphorylation. |
|
| B. |
Deletion of extracellular ectodomain |
|
| C. |
Mutation in ectodomain that prevents binding of EGF |
|
| D. |
Cell expresses EGF |
|
| E. |
Mutation in promoter that increases expression of EGF receptor |
|
| F. |
Dimerization of receptor without growth factor |
|
| G. |
Mutation in EGFR promoter that decreases expression of receptor |
Epidermal growth factor receptor is a transmembrane protein that spans the length of the cell membrane. It binds epidermal or epithelial growth factor on its surface to promote cell signalling that leads to cell proliferation.
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