Estrogen works by binding to the ER. It includes two types ER alpha and ER beta and the two receptors are highly homologous.  How might this be relevant in cancer?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Estrogen works by binding to the ER. It includes two types ER alpha and ER beta and the two receptors are highly homologous.  How might this be relevant in cancer? 

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Estrogen receptors(ES) are the protein molecules present inside the cell. Their activation takes place by the estrogen hormone. The estrogen receptors are of two classes- nuclear estrogen receptors and membrane estrogen receptors. 

ER alpha and ER beta are the nuclear estrogen receptors, both of them belong to the nuclear receptor family of intracellular receptors.  Different genes encode both these receptors. The estrogen receptors have an important role to play in the sexual maturation and gestation. 

 

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