The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction. Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63?
The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6 and E7 proteins govern the cell via altering cellular proteins. The E6 protein interacts with the tumor suppressor protein p53 and directs its ubiquitin-mediated destruction.
Can you elaborate about the P63 gene: its function and if it can be altered/mutated by HPV? If it does, what is the relationship between P53 and P63?
Thank you!
P63 genes provide instructions for the production of a tumor protein p63 (also known as p63). The p63 protein acts as a transcription factor, meaning that it attaches (binds) to certain areas of DNA and regulates the activity of certain genes.
This genetic code encodes a member of the p53 family of genetic elements. The active domains of the p53 family protein include the N-terminal transactivation domain, the DNA binding domain and the oligomerization domain. Some of these genetic variants and the use of other promoters result in a wide range of writing that incorporates different isoform codes that differ in their performance characteristics. These isoforms are active during skin development and care, stem / progenitor cell control in adults, heart growth and premature aging. Some isoforms have been found to protect the germline by removing oocytes or DNA-damaged testicular cells. Genetic modification is associated with ectodermal dysplasia, and cleft lip / palate syndrome 3 (EEC3); wrong hand / foot separation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip / palate; ADULT syndrome (acro-dermato-ungual-lacrimal tooth); organ-mammary syndrome; Rap-Hodgkin syndrome (RHS); facial fractures.
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