The following chromosomal aberration is found in nearly 90-95% of all patients who have chronic myelogenous leukemia. This is because the change brings the BCR and ABL genes in close proximity. BCR is responsible for cell growth, and ABL is a proto-oncogene... this favors uncontrolled growth. Which is the most accurate description of the aberration... chio moso me 9 Philad elphia chromosome 22 chromosome BCR ABL 22q11.2 (BCR) Oq34 1 (ABL) O Deletion O Translocation Inversion Duplication

Q: Cyclin D/cdk 4,6 inhibits retinoblastoma protein (Rb) binding to...., which ultimately affects gene…

A: Mutation in RB1 gene causes retinoblastoma. Due to this mutation cell is unable to control growth.…

Q: rms of the cell cycle, what would happen if there was a defect in the Rb prote made it unable to…

A: Rb protein is a tumor suppressor protein that is it suppresses the tumor from growing. Hence Rb…

Q: Part 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic…

A: Answer  The mode of inheritance shown in the above pedigree is of autosomal recessive

Q: Deletion of a cellular proto-oncogene is likely to be associated with cancer.

A: True

Q: Describe three types of genetic changes that commonly convert aproto-oncogene to an oncogene.…

A: The genetic alteration results in the advantage in growth of the cell. The 3 genetic change…

Q: What characteristics of the pedigree shown in Figure 23.1 suggest thatpancreatic cancer in this…

A: A pedigree is a pictorial representation that represents the history of a family, essential a tree…

Q: David Seligson and his colleagues examined levels of histone proteinmodification in prostate tumors…

A: The histone protein modification refers to the post translational modification of histones by…

Q: In the cells of patients with I-cell disease, their newly synthesized lysosomal proteins are not…

A: All organisms are made of numerous cells. Aptly cells are the building blocks of an organism.  Cells…

Q: A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies…

A: A gene that produces a protein that is essential for regulating cell division and death and is…

Q: Mutations in the RB gene are often associated with cancer. Explain how a mutation that results in a…

A: The cell cycle is the series of stages that allow the cell to pass from one cell division to…

Q: ''The chemical carcinogen dimethylbenz[a]anthra-cene (DMBA) must be an extraordinarily specific…

A: Abnormal growth of skin cells when exposed to sunlight causes skin cancer. They are originated from…

Q: Below you will find the normal p53 gene found on chromosome 17 and a mutated version of the gene.…

A: To solve such questions, we should know the corresponding complementarity between the bases and that…

Q: What is the importance of determining the patient's onset of menses and the number of pregnancies?

A: MM is 54 year old female.  She is diagnosed with  intraductal adenocarcinoma of the left breast 5…

Q: Describe/list the steps of how p53 can cause the GI phase to stall.

A: The p53 growth suppressor macromolecule plays a key role in the regulation of the cell cycle and…

Q: Some studies have pointed that mutant p53 proteins have gained a novel function by inactivating…

A: P53 is an important protein that is considered a tumor-suppressing gene. The presence of p53…

Q: Remember that DNA viruses inactivate tumor suppressor genes resulting in cancer. In Burkitt’s…

A: Translocation of c-myc occurs to one of the immunoglobulin foci. This leads to over expression of…

Q: 27 of 41 Mutations in two important cancer-critical genes, encoding p53 and Rb, respectively, are…

A: Normal cells in cancer are continuously transformed into the tumour or malignant cells due to a…

Q: Suggest a mechanism by which ARF leads to p53 build-up.

A: p53 protein gets activated when there is a damage in  DNA sequence which can be induced by any other…

Q: // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O…

A: CDK phosphorylate soecific target proteins. They required cyclin to be activate. CDK-cyclin…

Q: Cancer Cells need A.I.R in order to survive and proliferate. What does this stand for?   a.…

A: Oncogene activation requires genetic alterations in cellular protooncogenes. The result of these…

Q: The mutation associated with pancreatic cancer in the family in Figure23.1 was located in an exon of…

A: Mutation is a change in the sequence of genetic material either due to a mistake in replication or…

Q: The palladin gene, which plays a role in pancreatic cancer (see theintroduction to this chapter), is…

A: A disease is an abnormal condition that negatively impacts the structure and function of an…

Q: Which one of the following events is unlikely to beassociated with cancer?a. mutation of a cellular…

A: Cancer is basically the uncontrolled proliferation of abnormal or mutated cells in the body. It is…

Q: When the His− Salmonella strain used in the Ames testis exposed to substance X, no His+ revertants…

A: The Ames test, named after the developer Bruce Ames, is a chemical method to test chemicals such as…

Q: Describe the molecular process of X-chromosome inactivation.This description should include the…

A: Introduction: Female offspring has two X chromosomes, one of which is inherited from mother and the…

Q: Create a graph as a better way to display the data in the table 2) Determine which mutations (5q,…

A: Tumorigenesis or oncogenesis refers to the initial formation of cancer, where normal cells is prone…