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p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity

p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity
Transcribed Image Text:p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity
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