The NFAT family is a ubiquitous family of transcription factors. a. Under resting conditions, where is NFAT localized in a cell? b. Under activated conditions, where is NFAT localized in a cell? c. How is it released from its resting condition and permitted to relocalize? d. Immunosuppressant drugs such as cyclosporin act via inhibition of the calcineurin phosphatase. If NFAT is ubiqitous, how do you think these drugs might act with so few side effects on other signaling processes within the body?
The NFAT family is a ubiquitous family of transcription factors. a. Under resting conditions, where is NFAT localized in a cell? b. Under activated conditions, where is NFAT localized in a cell? c. How is it released from its resting condition and permitted to relocalize? d. Immunosuppressant drugs such as cyclosporin act via inhibition of the calcineurin phosphatase. If NFAT is ubiqitous, how do you think these drugs might act with so few side effects on other signaling processes within the body?
Biology 2e
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ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
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Problem 2VCQ: Figure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means...
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The NFAT family is a ubiquitous family of transcription factors.
a. Under resting conditions, where is NFAT localized in a cell?
b. Under activated conditions, where is NFAT localized in a cell?
c. How is it released from its resting condition and permitted to relocalize?
d. Immunosuppressant drugs such as cyclosporin act via inhibition of the calcineurin phosphatase. If NFAT is ubiqitous, how do you think these drugs might act with so few side effects on other signaling processes within the body?
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