In addition to the effect on ribonucleotide reductase, hydroxyurea causes changes at the gene expression level. In the presence of hydroxyurea, the transcription factor GATA2 becomes upregulated, turning on the expression of the γ-globin gene, while the transcription factor BCL11A, which is involved in the silencing of the γ-globin gene, is rendered inactive.Q6: BCL11A is a _________ and a transcriptional _________ of the γ-globin gene.

Gene silencing is a negative feedback process that controls gene expression and metabolism throughout an organism's lifespan as well as controls gene expression to determine cell destiny. 6) BCL11A is a silencer and a transcriptional repressor of the γ-globin gene. The BCL11A gene, is a transcription factor B-cell lymphoma/leukemia 11A, encodes a zinc-finger proteins that is mostly expressed in hematological and tissues of brain. BCL11A primarily acts as a transcriptional repressor and is essential for the development of the brain, hematological system, and the transition from fetal hemoglobin to adult. Transcription factors, genetic variants, and microRNAs all influence how this gene is expressed. BCL11A is the silencer meaning that it can silence gene expression. BCL11A is a powerful silencer of fetal hemoglobin both in rat and person. In collaboration with other factors, it regulates the beta-globin gene cluster.

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Anatomy and Physiology

A which is involved in the silencing of the y-globin gene, is rendered inactive. CL11A is a Land a transcriptional of the y-globin gene.

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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