APC is a ubiquitin ligase activated by M-cyclin Cdk What is the function of APC when bound to Cdc20? What is the function of APC when bound to Cdh1?

Q: Explain the role/importance of the localization of GTPase-activating protein (Ran- GAP) in BOTH…

A: The Ran protein is a member of the Ras superfamily of small GTPases. Ran regulates nucleocytoplasmic…

Q: Notably, one subunit of APC itself must remain phosphorylated at a single amino acid during sister…

A: In the phosphorylation reactions, proteins are reversibly modified. It is a regulatory reaction. The…

Q: Modify the diagram above to illustrate specific protein(s) that would participate in regulating this…

A: RB retinoblastoma gene is a tumor suppressor gene.

Q: Why doesn't Cdk1 active immediately upon binding to cyclin B? What other components of the cell’s…

A: It includes cell division, replication and growth. All these processes should be carried out in a…

Q: Now read this abstract from a 2013 journal article What is the authors' explanation of how Gal80p…

A: In the present system, GAL genes in Saccharomyces cerevisiae are regulated by the combined action of…

Q: As a researcher who studies cytoskeletal dynamics, you create a microtubule subunit that cannot…

A: Explanation: The critical concentration for the minus end of a polymer formed by these mutant…

Q: in a fat cell what is the result of activation of genes by PPAR gamma/activator proteins binding?…

A: Peroxisome proliferator - activated receptor(PPAR) gamma is a  nuclear receptor of subfamily 1,group…

Q: Explain the role/importance of the localization of  GTPase-activating protein (Ran-GAP)  in BOTH…

A: The Ran protein is a member of the Ras superfamily of small GTPases. Ran regulates nucleocytoplasmic…

Q: What purpose do scaffolding proteins serve in binding to Map kinase enzymes?

A: Introduction :- MAPKs are serine/threonine kinases that activate a variety of cytoplasmic and…

Q: Are any of the following feasibly linked to COVID-19 susceptibility? . Leucine zipper transcription…

A: COVID-19 is a pandemic which is caused by infection with SARS-CoV-2. Researchers found out a strong…

Q: ulate the cell cycle called tumar supressors

A: Tumor suppressor genes can be defined as the normal genes that affect the process of cell division…

Q: Stimulation of map kinase can help regulate cell division and cell mass. the following effects of…

A: Mitogen-activated protein kinases (MAP kinase) are protein kinases that autophosphorylate dual…

Q: Briefly describe how the cyclin D-cdk4/6 and cyclin E-cdk2 complexes regulate Retinoblastoma protein…

A: Retinoblastoma is the disease occurring in the retina of the eyes. This is basically eye cancer…

Q: Explain a mechanism for how a nuclear-encoded protein is targeted to the inner membrane of the…

A: Mitochondria possess specific replication, transcription, and translation machinery. All the…

Q: Which are the events causing loss-of-heterozygosity in somatic cells of RB+/RB− individuals?

A: The DNA (deoxyribonucleic acid) is the genetic material that is inherited by the progeny from the…

Q: What transcritpion factor is produced in the Nieuwkoop center in reponse to nuclear beta-catenin?(…

A: Transcription factors are usually the protein that have the capacity to increase or decrease the…

Q: RTK pathway leading to the phosphorylation of Rb to form p-Rb.

A: Receptor tyrosine kinase pathway helps in regulation of embryonic development aspects. Extracellular…

Q: which set of cells has a functional APC/C – those treated with siCon or those treated with siBRCA1?…

A: By designating particular proteins for degradation, the anaphase promoting complex/cyclosome (APC/C)…

Q: enzyme (Tyr 15 of phorylated, the en- -ylation state of any lows replication. The role of Cdk…

A: The cell cycle is highly regulated by different regulatory proteins that includes the cdc2 and…

Q: Suggest a mechanism by which ARF leads to p53 build-up.

A: p53 protein gets activated when there is a damage in  DNA sequence which can be induced by any other…

Q: Nucleation of straight, single line microfilaments is mediated by which of the following? Rho GTPase…

A: The nucleation of actin filaments is a tightly regulated process that involves several proteins.…

Q: We have studied Ras signal transduction pathway. In an experiment,  two different mutations were…

A: The cell proliferation depends on specific signalling processes that ultimately trigger some…

Q: Notch is an important transmembrane receptor that is present on the plasma membrane. Curiously, it…

A: Introduction When Exposed To Light In The Blue To Ultraviolet Range, The Green Fluorescent Protein…

Q: How does the activity of human p53 get regulated through the interaction of the transactivation…

A: p53 is basically a transcription factor that helps in suppressing the growth of the tumor. This…

Q: At what DNA strand is the ACTB gene coded? How many ACTB genes are coded in this region?

A: The ACTB gene codes for the Beta-actin protein, which is a member of the actin protein family. Actin…

Q: What is the effect of having fluctuating cyclin levels throughout the cell cycle, while the levels…

A: Cell cycle  It is a series of events in which cell duplicate it's organelles and divide.

Gene Interactions

When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.

Gene Expression

Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.