Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one. d) You determine that growth factor binding to this receptor ultimately results in the activation of the G1cyclin-Cdk4 complex, which phosphorylates and thereby inactivates RB. This leads to the release ofE2F and ultimately allows the cell to transition from G1 to S phase. (This process is depicted below)G, cyclinG1Cdk4RBE2FP

RB retinoblastoma gene is a tumor suppressor gene.

Answered: Modify the diagram above to illustrate…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one.

d) You determine that growth factor binding to this receptor ultimately results in the activation of the G1
cyclin-Cdk4 complex, which phosphorylates and thereby inactivates RB. This leads to the release of
E2F and ultimately allows the cell to transition from G1 to S phase. (This process is depicted below)
G, cyclin
G1
Cdk4
RB
E2F
P

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