Select the statements that accurately describe different ways that translocations could lead to cancer. A translocation breaks up the sequence of a gene for a protein that stimulates apoptosis. The resulting protein cannot function properly. A gene for a protein that stimulates apoptosis is placed next to a regulatory sequence that increases the expression of the gene. A translocation breaks up a gene that encodes a protein required to pass through mitotic checkpoints. The resulting protein cannot function normally. A gene for a protein that is involved in a mitotic checkpoint is placed next to the regulatory sequence of a different gene. The gene is now expressed at inappropriate times. A new sequence is added to a proto-oncogene. The modified gene now produces a new protein that increases the rate of cell division.

Q: Part 3C: Below is data from a pedigree trace of patients affected with mouse model of pancreatic…

A: Answer  The mode of inheritance shown in the above pedigree is of autosomal recessive

Q: In a few sentences, describe how p53 guards the genome. Include at least two specific ways that p53…

A: The TP53 ( Tumor protein 53) also known as P53. This gene codes for cell cycle regulatory proteins…

Q: . MAKE CONNECTIONS The p53 protein can activategenes involved in apoptosis. Review Concept 11.5,…

A: Cells are exposed to exogenous and endogenous compounds which cause DNA damage. It results in…

Q: Briefly describe how mitotic recombination can result in loss of heterozygosity (LOH) at tumor…

A: Loss of heterozygosity (LOH) is the loss of one parent's contribution to cell and can be caused by…

Q: Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell…

A: Need to find all the options that produce uncontrollable cell division  and to increase chance of…

Q: Several new cancer drugs inhibit the enzymes that either put acetyl groups on histones or take them…

A: Cancer in simple term can be referred to a set of diseases which are caused by the production of an…

Q: Translocation of a proto-oncogene to a chromosome region with reduced methylation increases its…

A: Abnormal sequences of DNA methylation, disturbed patterns of histone posttranslational modifications…

Q: examine the process of gene expression. Include the following: Explain the regulation of gene…

A: Introduction Gene Expression Is The Process Through Which Information From A Gene Is Used To Create…

Q: Testosterone is a hormone that affects gene expression. Only some cells in your body are affected by…

A: Testosterone is a type of hormone released by the human body. It’s essentially synthesized in men by…

Q: List the following steps of gene expression in eukaryotes in chronological order. Also indicate…

A: RNA processing refers to the series of events where the pre-mRNA is converted to mature RNA by…

Q: You decide to have your genome sequenced. The results come back and show that you have a…

A: Any abrupt change in the DNA causes mutation. This may or may not change the function of the cell.…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had…

A: BRCA1 is a tumor suppressor gene usually expressed in breast cells. It is responsible for repairing…

Q: In other words, the master regulator initiates a program of gene expression that narrow the…

A: Cell signalling

Q: In attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you…

A: The answer is none of these.The cell cycle is a tightly regulated process that controls the growth…

Q: Regulation of gene expression in eukaryotes can occur:

A: Transcription is the formation of mRNA from DNA.It occurs in nucleus. The translation is the…

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: RASL11A gene is a tumor suppressor gene associated with spontaneous tumor shrinkage in Tasmanian…

A: According to guidelines we have to answer the first question only. so please kindly post the…

Q: Identify 2 proteins important for cell cycle regulation and explain why they play a critical role in…

A: A cell cycle is the series of events through which cell grow and divides. The regulation of the cell…

Q: One example of an oncogene is ras. Ras is a G protein that is activated when growth factors bind to…

A: Activating mutations in proto-oncogenes that cause growth. Protooncogenes are the genes which causes…

Q: Which one of the following events is unlikely to beassociated with cancer?a. mutation of a cellular…

A: Cancer is basically the uncontrolled proliferation of abnormal or mutated cells in the body. It is…

Q: One example of an oncogene is ras. Ras is a G protein that is activated when growth factors bind to…

A: Cell cycle:  It is the sequence of events by which the genome of the cells gets duplicated and the…

Q: Which of these events do you think is likely to promote tumorigenesis in affected cells? Group of…

A: Tumorigenesis is the process of forming a tumor, which is an abnormal growth of cells.

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

A:

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Q: Apply the Key terms to fill in the blanks to demonstrate knowledge of cancer development. Key terms:…

A: 1. Regulator  2. Mutated 3.cell cycle 4.unrepaired 5. Check points.

Q: A disease is caused by having no functional protein produced from the kip gene. An individual has…

A: Mutations are alterations in the DNA sequence of an organism. Small changes, such as adding or…

Q: Which of the following chromosomal changes would be LEAST likely to cause the development of cancer?…

A: Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably.…

Q: You are studying a disease caused when the gene called BMP5 is not transcribed in osteoblasts. All…

A: In plants, animals, cell cultures, and bacteria, a reporter gene is characterized as a gene that is…

Q: "In most differentiated tissues, daughter cells retain a memory of gene expression patterns that…

A: The expression of specific genes inside each cell type is what causes cells to differentiate into…

Q: There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes,…

A: It is an uncontrollable cell division that get metastasized into surrounding tissues.

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.