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Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had breast cancer. BRCA1 is a tumor suppressor gene that is related to breast cancer. Why would Nicole be at higher risk for getting breast cancer at an earlier age than her sister, Francine, who inherited a normal BRCA1 allele from their mother? An individual who inherited two functional alleles of a tumor suppressor gene is less likely to eat highly carcinogenic foods. One mutant allele of a tumor suppressor gene increases the likelihood that the wild-type allele will also mutate. A person who inherited two functioning alleles of a tumor suppressor gene needs both alleles to mutate for tumors to develop. If an individual has even one mutation in a tumor suppressor gene, cancer will not be suppressed.

Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had breast cancer. BRCA1 is a tumor suppressor gene that is related to breast cancer. Why would Nicole be at higher risk for getting breast cancer at an earlier age than her sister, Francine, who inherited a normal BRCA1 allele from their mother? An individual who inherited two functional alleles of a tumor suppressor gene is less likely to eat highly carcinogenic foods. One mutant allele of a tumor suppressor gene increases the likelihood that the wild-type allele will also mutate. A person who inherited two functioning alleles of a tumor suppressor gene needs both alleles to mutate for tumors to develop. If an individual has even one mutation in a tumor suppressor gene, cancer will not be suppressed.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had breast cancer. BRCA1 is a tumor suppressor gene that is related to breast cancer. Why would Nicole be at higher risk for getting breast cancer at an earlier age than her sister, Francine, who inherited a normal BRCA1 allele from their mother? An individual who inherited two functional alleles of a tumor suppressor gene is less likely to eat highly carcinogenic foods. One mutant allele of a tumor suppressor gene increases the likelihood that the wild-type allele will also mutate. A person who inherited two functioning alleles of a tumor suppressor gene needs both alleles to mutate for tumors to develop. O If an individual has even one mutation in a tumor suppressor gene, cancer will not be suppressed.
Transcribed Image Text:Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had breast cancer. BRCA1 is a tumor suppressor gene that is related to breast cancer. Why would Nicole be at higher risk for getting breast cancer at an earlier age than her sister, Francine, who inherited a normal BRCA1 allele from their mother? An individual who inherited two functional alleles of a tumor suppressor gene is less likely to eat highly carcinogenic foods. One mutant allele of a tumor suppressor gene increases the likelihood that the wild-type allele will also mutate. A person who inherited two functioning alleles of a tumor suppressor gene needs both alleles to mutate for tumors to develop. O If an individual has even one mutation in a tumor suppressor gene, cancer will not be suppressed.
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