p53 Iis an impórtant tumor suppressor gene that is activated in response to a variety of stress signals. Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53 gene are found in almost every type of cancer. How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its function? O It no longer will act as activator of gene expression It no longer will act as repressor of gene expression It no longer will act as activator or repressor of gene expression O It no longer will act as coactivator or corepressor

p53 Iis an impórtant tumor suppressor gene that is activated in response to a variety of stress signals. Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53 gene are found in almost every type of cancer. How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its function? O It no longer will act as activator of gene expression It no longer will act as repressor of gene expression It no longer will act as activator or repressor of gene expression O It no longer will act as coactivator or corepressor

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 19RQ: A scientist notices that a cancer cell line fails to die when he adds an inducer of apoptosis to his...

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Concept explainers

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.

Question

p53 iš an important tumor suppressor gene that is activated in response to a variety of stress signals.
Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53
gene are found in almost every type of cancer.
How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its
function?
OIt no longer will act as activator of gene expression
O It no longer will act as repressor of gene expression
O It no longer will act as activator or repressor of gene expression
O It no longer will act as coactivator or corepressor

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