p53 Iis an impórtant tumor suppressor gene that is activated in response to a variety of stress signals. Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53 gene are found in almost every type of cancer. How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its function? O It no longer will act as activator of gene expression It no longer will act as repressor of gene expression It no longer will act as activator or repressor of gene expression O It no longer will act as coactivator or corepressor

p53 Iis an impórtant tumor suppressor gene that is activated in response to a variety of stress signals. Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53 gene are found in almost every type of cancer. How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its function? O It no longer will act as activator of gene expression It no longer will act as repressor of gene expression It no longer will act as activator or repressor of gene expression O It no longer will act as coactivator or corepressor

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter17: Developmental Genetics

Section: Chapter Questions

Problem 8TYU: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in...

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Concept explainers

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.

Question

p53 iš an important tumor suppressor gene that is activated in response to a variety of stress signals.
Upon activation it induces a cell cycle arrest or cell death. Hence, loss-of-function mutations in the p53
gene are found in almost every type of cancer.
How do you predict loss-of-function mutations in the DNA binding domain of the p53 protein affect its
function?
OIt no longer will act as activator of gene expression
O It no longer will act as repressor of gene expression
O It no longer will act as activator or repressor of gene expression
O It no longer will act as coactivator or corepressor

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