Biology 2e
Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 9, Problem 19RQ

A scientist notices that a cancer cell line fails to die when he adds an inducer of apoptosis to his culture of cells. Which hypothesis could explain why the cells fail to die?

  1. The cells have a mutation that prevents the initiation of apoptosis signaling.
  2. The cells have lost expression of the receptor for the apoptosis-inducing ligand.
  3. The cells overexpress a growth factor pathway that inhibits apoptosis.
  4. All of the above.

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A cell begins to undergo apoptosis due to stress. Which of the following are true about this cell? (select all that apply) The cell can exit apoptosis if the stressful factor is removed The cell has high levels of p53. The cell's DNA will inevitably degrade The cell may undergo mitosis before completing apoptosis
Upon learning about the mechanism of apoptosis, the question asked was; Is cytochrome c being released from mitochondria or is it being expressed by an induced nuclear gene and being produced in the cytosol. Which one of the following observations would provide the best evidence that it was being released from the mitochondria? Bcl2 blocks release of cytochrome c from mitochondria and also inhibits apoptosis Active Fas receptors trigger release of cytochrome c from mitochondria. Extracellular signals that block apoptosis do not produce cytosolic cytochrome c Caspase inhibitors block release of cytochrome c from the mitochondria

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