Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 9, Problem 33CTQ
A scientist notices that a cancer cell line shows high levels of phosphorylated ERK in the absence of EGF. What are two possible explanations for the increase in phosphorylated ERK? Be specific in which proteins are involved.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 9 Solutions
Biology 2e
Ch. 9 - Figure 9.8 HER2 is a receptor tyrosine kinase. In...Ch. 9 - Figure 9.10 In certain cancers, the GTPase...Ch. 9 - Figure 9.17 Which of the following statements...Ch. 9 - Figure 9.18 What advantage might biofilm...Ch. 9 - What property prevents the ligands of cell-surface...Ch. 9 - The secretion of hormones by the pituitary gland...Ch. 9 - Why are ion channels necessary to transport ions...Ch. 9 - Endocrine signals are transmitted more slowly than...Ch. 9 - A scientist notices that when she adds a small,...Ch. 9 - Where do DAG and IP3 originate? They are formed by...
Ch. 9 - What property enables the residues of the amino...Ch. 9 - Histamine binds to the H1 G-protein-linked...Ch. 9 - A scientist observes a mutation in the...Ch. 9 - What is the function of a phosphatase? A...Ch. 9 - How does NF-kB induce gene expression? A small,...Ch. 9 - Apoptosis can occur in a cell when the cell is...Ch. 9 - What is the effect of an inhibitor binding an...Ch. 9 - How does PKC’s signaling role change in response...Ch. 9 - A scientist notices that a cancer cell line fails...Ch. 9 - Which type of molecule acts as a signaling...Ch. 9 - Quorum sensing is triggered to begin when...Ch. 9 - A doctor is researching new ways to treat biofilms...Ch. 9 - What is the difference between intracellular...Ch. 9 - How are the effects of paracrine signaling limited...Ch. 9 - What are the differences between internal...Ch. 9 - Cells grown in the laboratory are mixed with a dye...Ch. 9 - Insulin is a hormone that regulates blood sugar by...Ch. 9 - The same second messengers are used in many...Ch. 9 - What would happen if the intracellular domain of a...Ch. 9 - If a cell developed a mutation in its MAP2K1 gene...Ch. 9 - What is a possible result of a mutation in a...Ch. 9 - How does the extracellular matrix control the...Ch. 9 - A scientist notices that a cancer cell line shows...Ch. 9 - What characteristics make yeasts a good model for...Ch. 9 - Why is signaling in multicellular organisms more...Ch. 9 - Pseudomonas infections are very common in hospital...
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