Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 9, Problem 2VCQ
Figure 9.10 In certain cancers, the GTPase activity of the RAS G-protein is inhibited. This means that the RAS protein can no longer hydrolyze GTP into GDP What effect would this have on downstream cellular events?
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The ras protein is a mutated G protein that lacks GTPase activity. How does the absence of this activity affect the adenylyl cyclase pathway?
The G-protein Ras is involved in proliferative signaling, and is mutated is a large fraction of human cancers. Almost all mutations in Ras mutate the glycine at codon 12. These mutations lock Ras in an active conformation. How will the GTPase activity of a Ras protein with a G12 mutation compare to a normal Ras protein without the mutation? (10 words maximum)
GTP binding proteins are molecular switches. How do GTP binding proteins work?
Provide two examples of GTP binding proteins that function in intracellular protein transport.
Make a drawing that illustrates the function of each of these proteins in their respective roles.
Predict the direct outcome of a mutation that:
Inhibits GTPase activity
Inhibits interaction with the GEF
Chapter 9 Solutions
Biology 2e
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- The G protein coupled receptor (GPCR) pathway elicits diverse intracellular responses in different cells. The basic steps of GPCR signaling are outlined in this diagram. Which of the following statements correctly describes the process of GPCR signaling? The GPCR activation is reversible after the signal of the ligand diminishes. The membrane-embedded enzyme uses GTP as a secondary messenger to initiate gene expression. The ligand attaches to both the GPCR and the membrane-embedded enzyme to activate the GPCR pathway. The ligand-bound GPCR sends a GTP molecule to an enzyme in the membrane and switches it into an active state.arrow_forwardA certain group of Brec-MUT cells expresses low levels of protein A, unlike the high expression levels of most Brec-MUT cells. Researchers determine that the cells have an excess of ATP and that there are no mutations in the gene encoding protein A. Describe a change in the Brec signaling pathway that would lead to the decreased expression of protein A even in the presence of Brec-MUT. Explain why B is able to bind to Brec but not to A.arrow_forwardHow would a mutation in ras that leads to formation of a Ras proteinwith no GTPase activity affect a cell’s response to insulin?arrow_forward
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