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Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 9, Problem 26CTQ
Cells grown in the laboratory are mixed with a dye molecule that is unable to pass through the plasma membrane. If a ligand is added to the cells, observations show that the dye enters the cells. What type of receptor did the ligand bind to on the cell surface?
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Students have asked these similar questions
Draw a diagram of a membrane receptor and include the following details. Include a depiction of the plasma membrane with which it is associated; label the locations of the extracellular space, the cytoplasm, and the ligand-binding domain.
Proteins in the plasma membrane are often the target of medicines.Discuss why you think this is the case. How would you determineexperimentally that a specific membrane protein was the target of adrug?
You perform a competition study on a GPCR. You have isolated the plasma membrane
from cells which contains the GPCR of interest. If an agonist and an inverse agonist
are at equal concentrations in your study but the inverse agonist has a 10 x higher
affinity for the receptor than the agonist, what would you expect to be the overall
outcome to be?
More of the agonist is bound and so most of the receptor is in its active conformation and is
stimulated
More of the inverse agonist is bound and so most of the receptor is in its inactive
conformation and is unstimulated.
Chapter 9 Solutions
Biology 2e
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The Cell Membrane; Author: The Organic Chemistry Tutor;https://www.youtube.com/watch?v=AsffT7XIXbA;License: Standard youtube license