Biology 2e
Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 9, Problem 5RQ

What property prevents the ligands of cell-surface receptors from entering the cell?

  1. The molecules bind to the extracellular domain.
  2. The molecules are hydrophilic and cannot penetrate the hydrophobic inferior of the plasma membrane.
  3. The molecules are attached to transport proteins that deliver them through the bloodstream to target cells.
  4. The ligands are able to penetrate the membrane and directly influence gene expression upon receptor binding.

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The G protein coupled receptor (GPCR) pathway elicits diverse intracellular responses in different cells. The basic steps of GPCR signaling are outlined in this diagram.   Which of the following statements correctly describes the process of GPCR signaling? The GPCR activation is reversible after the signal of the ligand diminishes. The membrane-embedded enzyme uses GTP as a secondary messenger to initiate gene expression. The ligand attaches to both the GPCR and the membrane-embedded enzyme to activate the GPCR pathway. The ligand-bound GPCR sends a GTP molecule to an enzyme in the membrane and switches it into an active state.
An SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and phosphotyrosine bind with equal affinity. As a result, MEK activity:   does not change with receptor dimerization and transautophosphorylation    decreases due to changes in Raf activation    increases with ligand binding-induced dimerization    decreases due to allosteric inhibition of SH2-domain binding
AAA is a protein found in both the cytosol as well as the nucleus. In this active state, it helps to facilitate the movement of proteins into and out of the nucleus. Specifically, AAA-alpha and AAA-beta binds to receptors on the nucleus and allows for materials to enter or exit through the channels associated with the receptors. They also play a role in dropping off cargo that import and export receptors hold onto. AAA functions are cotrolled by two other proteins: BBB and CCC. BBB binds onto AAA, while CCC removes BBB from AAA when they are bound. As a result, there is a BBB and CCC concentration gradient that forms between the cytososl and nucleus. During prophase I, is there a concentration gradient for BBB and CCC between the cytosol and the nucleus? Why? is this also the case during the other phases of meiosis or the cell cycle?

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