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The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase expression of several genes and promote cell proliferation as shown in the figure below. EGF Active EGFR Inactive EGFR P- Inactive EGFR Inactive Ras-GDP Ras-GTP Active Raf -P MEK - P NUCLEUS MAPK - P Active MAPK - P C-myc gene transcribed CYTOPLASM Cell proliferation Which of the following scenarios would result in increased expression of the c-myc gene? Select all that apply A homozygous mutation of the EGFR gene resulting in a deletion of the ligand binding domain A homozygous mutation of the ras gene so that Ras protein was not able to exchange GDP for GTP A homozygous mutation of the MAPK gene so that MAPK protein was always in

The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase expression of several genes and promote cell proliferation as shown in the figure below. EGF Active EGFR Inactive EGFR P- Inactive EGFR Inactive Ras-GDP Ras-GTP Active Raf -P MEK - P NUCLEUS MAPK - P Active MAPK - P C-myc gene transcribed CYTOPLASM Cell proliferation Which of the following scenarios would result in increased expression of the c-myc gene? Select all that apply A homozygous mutation of the EGFR gene resulting in a deletion of the ligand binding domain A homozygous mutation of the ras gene so that Ras protein was not able to exchange GDP for GTP A homozygous mutation of the MAPK gene so that MAPK protein was always in

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase expression of several genes and promote cell proliferation as shown in the figure below. EGF Active EGFR Inactive EGFR P- Inactive EGFR Inactive Ras-GDR Ras-GTP Active Raf -P МЕК- Р NUCLEUS МАРК-Р Active МАРК-Р C-myc gene transcribed CYTOPLASM Cell proliferation Which of the following scenarios would result in increased expression of the c-myc gene? Select all that apply. A homozygous mutation of the EGFR gene resulting in a deletion of the ligand binding domain A homozygous mutation of the ras gene so that Ras protein was not able to exchange GDP for GTP A homozygous mutation of the MAPK gene so that MAPK protein was always in a phosphorylated state A homozygous mutation of the ras gene so that Ras protein was not able to hydrolyze GTP for GDP
Transcribed Image Text:The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase expression of several genes and promote cell proliferation as shown in the figure below. EGF Active EGFR Inactive EGFR P- Inactive EGFR Inactive Ras-GDR Ras-GTP Active Raf -P МЕК- Р NUCLEUS МАРК-Р Active МАРК-Р C-myc gene transcribed CYTOPLASM Cell proliferation Which of the following scenarios would result in increased expression of the c-myc gene? Select all that apply. A homozygous mutation of the EGFR gene resulting in a deletion of the ligand binding domain A homozygous mutation of the ras gene so that Ras protein was not able to exchange GDP for GTP A homozygous mutation of the MAPK gene so that MAPK protein was always in a phosphorylated state A homozygous mutation of the ras gene so that Ras protein was not able to hydrolyze GTP for GDP
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