The cell enters g1 and cyclin D binds with CDK4/6 Increases in cyclin D expression prevent p21/p27 from inhibiting cyclin E/CDK2 Rb is hypo-phosphorylated E2F is no longer repressed and induces expression of E2F and cyclin E The cell enters S phase and cyclin A binds to CDK2 cyclin A binds to CDC 2 > Cell enters G2 and cyclin B binds CDC 2 Cell enters M phase and proliferates Rb is hyperphosphorylated Upsteam signaling pathways lead to increase of expression of Cyclin D put in correct order from 1-10
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
The cell enters g1 and cyclin D binds with CDK4/6
Increases in cyclin D expression prevent p21/p27 from inhibiting cyclin E/CDK2
Rb is hypo-phosphorylated
E2F is no longer repressed and induces expression of E2F and cyclin E
The cell enters S phase and cyclin A binds to CDK2
cyclin A binds to CDC 2 >
Cell enters G2 and cyclin B binds CDC 2
Cell enters M phase and proliferates
Rb is hyperphosphorylated
Upsteam signaling pathways lead to increase of expression of Cyclin D
put in correct order from 1-10
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Solved in 2 steps
