Which of the following would most likely mimic Rb loss? Rb mutant where the phosphosites are mutated to alanine G1 cyclin with a shorter half-life Constitutively active E2F Ras GTPase mutant with increased hydrolysis activity

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Which of the following would most likely mimic Rb loss?
Rb mutant where the phosphosites are mutated to alanine
G1 cyclin with a shorter half-life
Constitutively active E2F
Ras GTPase mutant with increased hydrolysis activity
Loss of Ras-GEF
Transcribed Image Text:Which of the following would most likely mimic Rb loss? Rb mutant where the phosphosites are mutated to alanine G1 cyclin with a shorter half-life Constitutively active E2F Ras GTPase mutant with increased hydrolysis activity Loss of Ras-GEF
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