Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger mutations that are along for the ride. Just because the tumors with a strong environmental component possess a higher frequency of mutations does not mean more oncogenes or more failure of tumor suppressors is occurring. Hematologic childhood cancers have a lower frequency of mutations than tumors with a strong environmental component such as lung cancers and melanoma; WHY?
Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger mutations that are along for the ride. Just because the tumors with a strong environmental component possess a higher frequency of mutations does not mean more oncogenes or more failure of tumor suppressors is occurring. Hematologic childhood cancers have a lower frequency of mutations than tumors with a strong environmental component such as lung cancers and melanoma; WHY?
Hematologic childhood cancer can develop in any part of the body, including the blood and lymph node systems, the brain and spinal cord (central nervous system), kidneys, and other organs and tissues in children.
The majority of the time, the cause of childhood malignancies is unknown. Even if they develop in the same place of the body, childhood malignancies can behave significantly differently than adult cancers.
When healthy cells change and grow out of control, cancer develops. These cells produce a mass called a tumor in most kinds of cancer. Tumors can be malignant or noncancerous. A malignant tumor is one that has the potential to grow and spread to other regions of the body. The term "benign tumor" refers to a tumor that can develop but does not spread to other parts of the body.
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