A cultured mouse cell line has a mutation in a gene encoding a ribosomal protein. The mutant protein impairs the fidelity of translation such that incorrect amino acids are incorporated at higher rates than normal during protein synthesis. It also slows the rate of mRNA translation and increases the duration of the cell cycle, i.e., the mutant cells grow and divide more slowly. Researchers noted that these cells express higher levels of chaperone proteins than normal cells. Which of the following is the most likely explanation for the elevated chaperone levels. Only one answer is considered correct.Chaperone upregulation is triggered because the mutation in the DNAsequence of the ribosomal protein gene leads to the presence ofabnormal misfolded DNA.chaperone upregulation is triggered by the slower rate of mRNAtranslation.chaperone upregulation is triggered by the increase in cell cycleduration (cell division time).chaperone upregulation is triggered by higher levels of misfoldedproteins arising from elevated amino acid misincorporation duringsynthesis.chaperone upregulation is triggered by reduced cellular ATPconsumption caused by the slower rate of translation.

Chaperones are a kind of protein with similar properties that aid in protein folding. These proteins…

Answered: A cultured mouse cell line has a…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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A cultured mouse cell line has a mutation in a gene encoding a ribosomal protein. The mutant protein impairs the fidelity of translation such that incorrect amino acids are incorporated at higher rates than normal during protein synthesis. It also slows the rate of mRNA translation and increases the duration of the cell cycle, i.e., the mutant cells grow and divide more slowly. Researchers noted that these cells express higher levels of chaperone proteins than normal cells. Which of the following is the most likely explanation for the elevated chaperone levels.

Only one answer is considered correct.
Chaperone upregulation is triggered because the mutation in the DNA
sequence of the ribosomal protein gene leads to the presence of
abnormal misfolded DNA.
chaperone upregulation is triggered by the slower rate of mRNA
translation.
chaperone upregulation is triggered by the increase in cell cycle
duration (cell division time).
chaperone upregulation is triggered by higher levels of misfolded
proteins arising from elevated amino acid misincorporation during
synthesis.
chaperone upregulation is triggered by reduced cellular ATP
consumption caused by the slower rate of translation.

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