You are analyzing the activity of the protein p53 in two different cell types. You notice that p53 has the same primary structure in both cells, but has a different function in each cell. What could be the reason for the functional difference in this case? A. p53 mRNA has been spliced differently in each cell type. B. p53 is phosphorylated on some amino acid residues in its transactivation domain in one cell type but not in the other cell type. C. The tetramerization domain of p53 is acetylated at the same amino acid residues in both cell types. D. All of the above E. B and C only

Human Anatomy & Physiology (11th Edition)
11th Edition
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Chapter1: The Human Body: An Orientation
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You are analyzing the activity of the protein p53 in two different cell types. You notice that p53 has the same primary structure in both cells, but has a different function in each cell. What could be the reason for the functional difference in this case?

A. p53 mRNA has been spliced differently in each cell type.

B. p53 is phosphorylated on some amino acid residues in its transactivation domain in one cell type but not in the other cell type.

C. The tetramerization domain of p53 is acetylated at the same amino acid residues in both cell types.

D. All of the above

E. B and C only

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