Would the viral insertion of a proto-oncogene into a region of genomic DNA with non-acetylated histones be likely to lead to a cancerous cell? Explain. (Read the answer options VERY carefully!) A. NO it would not lead to a cancerous cell. Non-acetylated histones = condensed chromatin so viral insertion here means there would be no transcription so this would not increase levels of the protein. B. NO it would not lead to a cancerous cell. Non-acetylated histones = open chromatin so viral insertion here means there would be high levels of transcription and this would increase the levels of the protein C. YES it would lead to a cancerous cell. Non-acetylated histones = condensed chromatin so viral insertion here means there would be no transcription so this would not increase levels of the protein. D. YES it would lead to a cancerous cell. Non-acetylated histones = open chromatin so viral insertion here means there would be high levels of transcription and this would increase the levels of the protein E. Not enough information

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Would the viral insertion of a proto-oncogene into a region of genomic DNA with non-acetylated histones be likely to lead to a cancerous cell? Explain. (Read the answer options VERY carefully!)


A. NO it would not lead to a cancerous cell. Non-acetylated histones = condensed chromatin so viral insertion here means there would be no transcription so this would not increase levels of the protein.
B. NO it would not lead to a cancerous cell. Non-acetylated histones = open chromatin so viral insertion here means there would be high levels of transcription and this would increase the levels of the protein
C. YES it would lead to a cancerous cell. Non-acetylated histones = condensed chromatin so viral insertion here means there would be no transcription so this would not increase levels of the protein.
D. YES it would lead to a cancerous cell. Non-acetylated histones = open chromatin so viral insertion here means there would be high levels of transcription and this would increase the levels of the protein
E. Not enough information
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