You are a researcher studying the genetic effects that lead to breast cancer. You discover a new miRNA that is highly expressed in breast cancer cells as compared to normal breast cells. So you plan an experiment to see what happens to the breast cancer cells when the gene for this new miRNA is deleted. When you delete the gene for this miRNA in these cells, you observe that the rate in which the breast cancer cells pass through the G1-S checkpoint of the cell cycle decreases, therefore slowly down the growth and division of these cells. You also notice that the rate of protein synthesis of BRCA1 is increased. Based on this information, which of the following statements would be supported by these results?a) The newly discovered miRNA likely binds to and blocks translation of the BRCA1 mRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are more likely to enter S phase, followed by G2 and mitosis.b ) The newly discovered miRNA likely binds to and blocks translation of the BRCA1 mRNA, therefore leading to more production of BRCA1 tumor suppressor protein in breast cancer cells. As a result, these cells are less likely to enter S phase and will remain in G1c) The BRCA1 protein likely binds to and blocks translation of the newly discovered miRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are more likely to enter S phase, followed by G2 and mitosis.d) he BRCA1 protein likely binds to and blocks translation of the newly discovered miRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are less likely to enter S phase and will remain in G1.

BRCA1 It is a human tumor suppressor gene and suppress the growth of tumor cells.

Answered: . Based on this information, which of…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 9QP: What is the difference between a proto-oncogene and a tumor-suppressor gene?

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You are a researcher studying the genetic effects that lead to breast cancer. You discover a new miRNA that is highly expressed in breast cancer cells as compared to normal breast cells. So you plan an experiment to see what happens to the breast cancer cells when the gene for this new miRNA is deleted. When you delete the gene for this miRNA in these cells, you observe that the rate in which the breast cancer cells pass through the G1-S checkpoint of the cell cycle decreases, therefore slowly down the growth and division of these cells. You also notice that the rate of protein synthesis of BRCA1 is increased. Based on this information, which of the following statements would be supported by these results?

a) The newly discovered miRNA likely binds to and blocks translation of the BRCA1 mRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are more likely to enter S phase, followed by G2 and mitosis.
b ) The newly discovered miRNA likely binds to and blocks translation of the BRCA1 mRNA, therefore leading to more production of BRCA1 tumor suppressor protein in breast cancer cells. As a result, these cells are less likely to enter S phase and will remain in G1
c) The BRCA1 protein likely binds to and blocks translation of the newly discovered miRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are more likely to enter S phase, followed by G2 and mitosis.
d) he BRCA1 protein likely binds to and blocks translation of the newly discovered miRNA, therefore leading to less production of BRCA1 protein in breast cancer cells. As a result, these cells are less likely to enter S phase and will remain in G1.

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