As discussed in Lipids 3, SREBPs are a type of transcription factor involved in lipid homeostasis. SREBPs regulate the expression of gene that encode for anabolic enzymes. Normally SREBPs are degraded within 3 hours. Pancreatic cancer cells prevent this from happening, which increases cholesterol production within the tumor. If maintaining SREBPs for a longer period of time increases lipid synthesis, then these transcription factors are: O introducing a point mutation within the mRNA, causing the ribosome to synthesize a better protein O binding to the promoter and preventing RNA polymerase from accessing the transcription start site O introducing a premature stop codon within the mRNA, causing the ribosome to terminate translation O binding upstream of the promoter and recruiting RNA polymerase to the transcription start site binding to the origin of replication and recruiting DNA polymerase for bidirectional synthesis
As discussed in Lipids 3, SREBPs are a type of transcription factor involved in lipid homeostasis. SREBPs regulate the expression of gene that encode for anabolic enzymes. Normally SREBPs are degraded within 3 hours. Pancreatic cancer cells prevent this from happening, which increases cholesterol production within the tumor. If maintaining SREBPs for a longer period of time increases lipid synthesis, then these transcription factors are: O introducing a point mutation within the mRNA, causing the ribosome to synthesize a better protein O binding to the promoter and preventing RNA polymerase from accessing the transcription start site O introducing a premature stop codon within the mRNA, causing the ribosome to terminate translation O binding upstream of the promoter and recruiting RNA polymerase to the transcription start site binding to the origin of replication and recruiting DNA polymerase for bidirectional synthesis
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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