Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase protein, called Mdm2. Over expression of Mdm2 destabilizes p53. Another protein p19ARF inhibits the activity of Mdm2, thus stabilizing p53. Loss of p19ARF function converts normal cells into cancer cells With the above information, which of the following statements are true? O Mdm2 is a tumor suppressor gene but p19ARF is an oncogene Both Mdm2 & P19ARF are oncogenes Both Mdm2 & P19ARF are tumor suppressor genes O Mdm2 is an oncogene but p19ARF is a tumor suppressor gene

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter12: Genes And Cancer
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Problem 15QP: Which of the following mutations will result in cancer? a. homozygous recessive mutation in a...
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Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase
protein, called Mdm2.
Over expression of Mdm2 destabilizes p53.
Another protein p19ARF inhibits the activity of Mdm2, thus stabilizing p53.
Loss of p19ARF function converts normal cells into cancer cells
With the above information, which of the following statements are true?
Mdm2 is a tumor suppressor gene but p19ARF is an oncogene
Both Mdm2 & P19ARF are oncogenes
Both Mdm2 & P19ARF are tumor suppressor genes
O Mdm2 is an oncogene but p19ARF is a tumor suppressor gene
Transcribed Image Text:Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase protein, called Mdm2. Over expression of Mdm2 destabilizes p53. Another protein p19ARF inhibits the activity of Mdm2, thus stabilizing p53. Loss of p19ARF function converts normal cells into cancer cells With the above information, which of the following statements are true? Mdm2 is a tumor suppressor gene but p19ARF is an oncogene Both Mdm2 & P19ARF are oncogenes Both Mdm2 & P19ARF are tumor suppressor genes O Mdm2 is an oncogene but p19ARF is a tumor suppressor gene
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