A partial DNA sequence, a partial MRNA transcript, and part of the CFTR polypeptide in a cystic fibrosis patient are shown in the diagram below. DNA 3 TAACCAČ MRNA 5 Polypeptide A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide. B. Is this a "true" frameshift mutation? Why or why not? C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation? answer. our
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
 alt="Cystic fibrosis is a life-threatening disease that causes thick, sticky mucus to build up in areas of the body, including the lungs. Scientists are studying CFTR, the gene
associated with cystic fibrosis in humans. In the majority of cystic fibrosis patients, the same mutation is seen in the same location on the CFTR geně.
A partial DNA sequence, a partial MRNA transcript, and part of the normal polypetide that the makes up the CFTR protein that the CFTR gene codes for are shown in
the diagram below.
DNA 3
MRNA 5
AUC
Polypeptide
A partial DNA sequence, a partial MRNA transcript, and part of the CFTR polypeptide in a cystic fibrosis patient are shown in the diagram below.
DNA 3
CACAA
MRNA 5
Polypeptide
Gly
A Describe the change in the DNA sequence, the effect on the MRNA, and the effect on the polypeptide.
B. Is this a "true" frameshift mutation? Why or why not?
C. Would a single base insertion at the beginning of the gene have a larger or smaller effect on the resulting polypeptide than the CFTR mutation?
answer.
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