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a often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life?  What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait? Is there one mutant copy sufficient

a often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life?  What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait? Is there one mutant copy sufficient

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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If children with hereditary retinoblastoma often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life?  What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait?

Is there one mutant copy sufficient to predispose a person to develop the cancer or two copies are needed to develop retinoblastoma as a cancer?

 

(a) Hereditary retinoblastoma Loss of functional Rb allele RB RB RB RB Somatic retinal cell Homozygous cell gives rise to tumors in retina (b) Sporadic retinoblastoma Loss of 1st Loss of 2nd functional Rb allele functional Rb allele RB RB+ RB RB RB RB Homozygous cell gives rise to tumors in retina Somatic retinal cell Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company
Transcribed Image Text:(a) Hereditary retinoblastoma Loss of functional Rb allele RB RB RB RB Somatic retinal cell Homozygous cell gives rise to tumors in retina (b) Sporadic retinoblastoma Loss of 1st Loss of 2nd functional Rb allele functional Rb allele RB RB+ RB RB RB RB Homozygous cell gives rise to tumors in retina Somatic retinal cell Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company
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