Answered: a often survive until adulthood and…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Based on the figure below:

If children with hereditary retinoblastoma often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life? What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait?

Is there one mutant copy sufficient to predispose a person to develop the cancer or two copies are needed to develop retinoblastoma as a cancer?

(a) Hereditary retinoblastoma
Loss of
functional
Rb allele
RB
RB
RB
RB
Somatic retinal
cell
Homozygous cell
gives rise to
tumors in retina
(b) Sporadic retinoblastoma
Loss of 1st
Loss of 2nd
functional
Rb allele
functional
Rb allele
RB
RB+
RB
RB
RB
RB
Homozygous cell
gives rise to
tumors in retina
Somatic retinal
cell
Lodish et al., Molecular Cell Biology, 9e, © 2021 W. H. Freeman and Company

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