Tumor suppressor genes and oncogenes are implicated in carcinogenesis. However, one can predict whether a gene potentially encodes for a protein that influences carcinogenesis by examining their mutational profile. You sequence the genome of 4 cancers and identify 3 genes of interest. Which of the following genes has the best potential to an oncogene?   Tumor 1 Tumor 2 Tumor 3 Tumor 4 Gene A S24F, N465T R33T T345S, G366R P367E, P368Y Gene B S34R, F360I S34R V254I S34E, T67Y Gene C S24F, I322E   C255I, E344D S34E, P367E

Q: Personalized cancer treatments involve identifying specific pathways in an individual tumor and…

A: Introduction Cancer is defined as a condition which is characterised by uncontrolled mitosis. In…

Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…

A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…

Q: Describe the general process of cell signalling pathways: what events take place for a signal to…

A: * mainly there are Three Stages of Cell Signaling . The first one is reception and here the signal…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: they argued that promoter switching may be correlated with cancer development and progression…

A: A DNA (deoxyribonucleic acid) sequence where the protein binds and initiates the transcription of…

Q: Which of the following statements are true about the rate of mutation in tumor cells (select all…

A: Chromosome rearrangements, which occur at high rates due to aneuploidy, an aberrant chromosome…

Q: How can researchers pinpoint the particular driver mutations most responsible for the cancer…

A: The development of cancer is an evolutionary process at the cellular level. Several mutations…

Q: Given the following scenario, indicate if this will ‘promote’ or ‘prevent’ cancer development: An…

A: Bcl-2, or B-cell lymphoma 2, is a protein that plays a crucial role in regulating apoptosis…

Q: Cancer is a major public health problem.  Both inherited genes and environmental factors play a role…

A: Cancer has become a major global health issue for some time. Cancers occur by environmental…

Q: what category of cancer-related genes is it possible to find inherited variants that are associated…

A: Answer is option 3.

Q: 1. For each of the following genes, categorize them as a tumor suppressor gene or a protooncogene.…

A: Bcl-2 gene is a protooncogene.The Bcl-2 can act as a barrier to apoptosis and and facilitate the…

Q: MSH2 is a gene commonly associated with HNPCC (Hereditary nonpolyposis colorectal cancer). This gene…

A: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an inherited…

Q: What genetic material was used in this research?" 2. How does the completion of this research…

A: Cancer: It is a diseases that occur due to the uncontrolled division of cells. When the normal cells…

Q: Give the correct DNA template for this bacterial gene segment (GGG UCG ACA CỤC UUU). ***"Please use…

A: Since you have posted a question with multiple sub- parts,we will solve the first three sub-parts…

Q: The myc oncogene increases expression of the glutamine transporter and glutaminase that converts…

A: Cancer is a disease defined by the uncontrolled development of a group of abnormal cells that can…

Q: Discuss the interplay between genetics and environment in the development of cancer (it would be…

A: Research on several diseases have found that the cause of diseases are not only environmental or…

Q: Describe error prone polymerases and the process of translesion synthesis (TLS). In regards to tumor…

A: Translesion synthesis (TLS) is a method of overcoming stopped replication in which particular…

Q: Cancer often results from a multistage process involving an initiating event (mediated by a viral…

A: Phorbol esters are a group of chemicals that are found in many plants. They are the ester…

Q: Suppose Nicole recently learned that she inherited a mutant BRCA1 allele from her mother, who had…

A: BRCA1 is a tumor suppressor gene usually expressed in breast cells. It is responsible for repairing…

Q: The decision by some high-risk women to have their breasts removed to prevent the possibility of…

A: The type of gene that possesses the potential to cause cancer as a result of mutation is referred to…

Q: 7) The protein VEGF plays an important role in stimulating the formation of new blood vessels. In…

A: VEGF ( vascular endothelial growth factor ) is responsible for the growth of new vessels. In…

Q: Match the following statements to the type of gene they describe. ✓Encode proteins that promote cell…

A: Tumor supressor genes are those whose deletion or under expression may cause cancer. They include…

Q: Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation…

A: The cells are basic units of life. When any mutation in the gene takes place due to any radiation or…

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: The Human papillomavirus (HPV) has been linked to an increased risk of cervical cancer. The HPV E6…

A: P63 genes provide instructions for the production of a tumor protein p63 (also known as p63). The…

Q: Cancer Cells need A.I.R in order to survive and proliferate. What does this stand for?   a.…

A: Oncogene activation requires genetic alterations in cellular protooncogenes. The result of these…

Q: Some initial studies looking at the carcinogenicity of tobacco products took extracts from those…

A: Introduction: When we inhale cigarette smoke, tar, a sticky, brown material, gathers in our lungs.…

Q: Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger…

A: Hematologic childhood cancer can develop in any part of the body, including the blood and lymph…

Q: Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell…

A: p53 is a tumor suppressor gene but if p53 gets mutated then this protein is not able to bind to the…

Q: Which of the following are true for the c-myc gene? Select all that apply

A: Myc is a group of regulator genes that code for transcription factors. c-myc is one of the genes in…

Q: Please distinguish driver and passenger mutations in cancer.

A: Driver mutations: Mutations in known oncogenes that help cells establish or maintain the transformed…

Q: You are studying cancer progression in mice. Your results show the following pathway in which two…

A: Nature of given proteins in cell division and cancer.

Q: Of the following choices a loss of function mutation would most lukely contribute to cancer onset if…

A: Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external…

Q: There are three general categories of effects resulting from exposure to low doses of radiation.…

A: Radiations caused by nuclear accidents are of great concern to the health and life of the people…

Q: On the image, you can see the results of a DNA microarray used for cancer prognosis, where tissue…

A: DNA microarray is the molecular biology technology that is used to detect the expression of multiple…