Which of the following statements are true about the rate of mutation in tumor cells (select all that apply)? A. Mutation rate of tumor cells is reduced compared to normal cells of the same tissue type B. Mutation rate of tumor cells is unchanged compared to normal cells of the same tissue type C. Mutation rate in tumor cells is higher compared to normal cells of the same tissue type D. Affected by genome instability within the tumor cells
Which of the following statements are true about the rate of mutation in tumor cells (select all that apply)?
| A. |
Mutation rate of tumor cells is reduced compared to normal cells of the same tissue type |
|
| B. |
Mutation rate of tumor cells is unchanged compared to normal cells of the same tissue type |
|
| C. |
Mutation rate in tumor cells is higher compared to normal cells of the same tissue type |
|
| D. |
Affected by genome instability within the tumor cells |
Chromosome rearrangements, which occur at high rates due to aneuploidy, an aberrant chromosome balance, are the cause of the mutation of cancer cells and tumorigenic cell lines in culture. Contrastingly, the mutation rates of cancer cells are 100 times more as opposed to the 10-12 mutation rates of normal diploid cells to recessive gene phenotypes.
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